Convenient and Efficient Synthesis of 1,1-Bis-(4-alkylthiophenyl)-1-alkenes via Tandem Friedel-Crafts Acylation and Alkylation of Sulfides and Acyl Chlorides
Authors: Jiaxi Xu a; Jiakun Xia a; Yu Lan a
| Affiliation: | a Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University. Beijing. China |
DOI: 10.1080/00397910500187373
Publication Frequency: 24 issues per year
Subject: Organic Chemistry;
Formats available: HTML (English) : PDF (English)
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Abstract1,1-Bis(4-alkylthiophenyl)-1-alkenes were conveniently and efficiently prepared from alkyl phenyl sulfides and acyl chlorides via a tandem Friedel-Crafts acylation and alkylation in the presence of anhydrous aluminum chloride. The scope, limitation, and mechanism of the tandem reaction were also discussed. |
| Keywords: Acylation; alkene; alkylation |